Metoclopramide in gastrooesophageal reflux.
نویسندگان
چکیده
In 30 patients with gastrooesophageal reflux, intravenous metoclopramide (Maxolon) has been shown to increase the gastrooesophageal sphincter pressure. The rise is dose-related until a maximum pressure, proportional to the resting sphincter tone, is reached. The effect is reversed by atropine. Peristaltic waves are increased in pressure by metoclopramide.In 18 patients with gastrooesophageal reflux intravenous metoclopramide diminished the frequency of reflux episodes and increased the rate at which the oesophagus emptied itself of an acid load.
منابع مشابه
Effect of intravenous metoclopramide on gastrooesophageal reflux.
The effect of intravenous metoclopramide was studied radiologically in 40 patients with gastrooesophageal reflux. In no patient was reflux significantly diminished.
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Data on the natural course of gastrooesophageal reflux disease are sparse. One hundred and sixty six patients with typical reflux symptoms (heartburn and/or acid regurgitation) and pathologic pH monitoring (reflux time > 8.2% upright and/or > 3.0% supine) were studied. The patients were followed up by questionnaire and interview for a mean of 41 (seven to 86) months after diagnosis of reflux di...
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عنوان ژورنال:
- Gut
دوره 14 4 شماره
صفحات -
تاریخ انتشار 1973